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Overview of DHEA: Its Role and Functions


Written by Dr. Chris Smith, Updated on February 21st, 2025
Reading Time: 2 minutes
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DHEA (Dehydroepiandrosterone) is a steroid hormone playing an integral role as the precursor for sex hormones like Testosterone and Estrogen. Acting as a mild androgen, DHEA effects are associated with masculine physiological properties. Androgens are hormones produced by both sexes, albeit more abundantly in males, with testosterone being the most well-known. Simultaneously, DHEA forms the basis for several other hormones like Testosterone and Estrogen, primarily transforming into the steroid Androstenedione. DHEA is primarily excreted by the Adrenal glands, with the brain and the intestines releasing minor amounts. Men have high DHEA levels until they hit approximately thirty years old, with many resorting to DHEA supplements to ward off illnesses and enhance their health and wellness.

Potential Health Benefits of DHEA Usage

Although most of the research on DHEA is still in its infancy, there exist several promising studies indicating possible health benefits. Small-scale research initiatives have suggested that DHEA supplementation could help manage afflictions such as adrenal insufficiency, osteoporosis, lupus, obesity, and depression. Additionally, evidence suggests that DHEA might aid in sexual problems, including erectile dysfunction and vaginal atrophy. However, research accuracy remains inconsistent due to inadequate studies.

Lower levels of circulating DHEA have been associated with health issues such as HIV, Type 2 Diabetes, and anorexia. Thus, DHEA supplementation could be a useful adjunct treatment to alleviate symptoms and effects of these conditions. Some proponents also claim that DHEA has therapeutic benefits in boosting strength, immunity, and psychological function in older individuals. To ascertain appropriate dosage and use, always consult a trusted health professional.

DHEA: Medical and Supplemental Uses

DHEA dosages lack universal standards, with studies mostly using dosages between 25mg and 200mg, and occasionally even higher. Each condition demands specific dosage requirements. Importantly, DHEA cannot be obtained naturally from dietary sources and is either endogenously produced by the body or created synthetically.

Possible Side Effects of DHEA Treatment

The use of DHEA often accompanies side effects such as congestion, insomnia, fatigue, and headaches. Hormonal inflation in women can lead to mood swings, acne, and irregular periods. Overdosing with DHEA might cause masculinization symptoms, including a deeper voice and facial hair growth. For men, higher doses could potentially induce high blood pressure and excess breast tissue. As a result, it is essential to consult with a healthcare professional before starting DHEA supplementation.

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