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Introduction to Sermorelin Therapy


Written by Dr. Chris Smith, Updated on February 10th, 2025
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Sermorelin Acetate, a truncated variant of the hypothalamic secretagogue Growth Hormone Releasing Hormone (GHRH), surpasses injectable HGH therapy on various fronts such as initial cost, long-term expenses, and physiological benefits. Some patients report higher life quality when combining Sermorelin and testosterone injections over using injectable HGH shots and low testosterone replacement protocols.

Mechanism of Sermorelin

By joining particular receptors, Sermorelin boosts the production of the body's innate growth hormone (HGH). Essentially, it invigorates the pituitary gland similarly to Growth Hormone Releasing Hormone, which in turn stimulates HGH production. Even older individuals and those with HGH deficiency can experience the benefits, as it stimulates the still-functioning pituitary gland to secrete HGH.

Benefits of Sermorelin

When HGH levels rise, the body responds through an anabolic effect on the tissues, bringing numerous health advantages. Sermorelin, composed of 29 out of the 44 amino acids found in GH RH, enhances Human Growth Hormone (HGH) secretion by the pituitary gland, particularly in individuals with hypopituitarism or adult-onset growth hormone deficiency. This outcome is attributed to an increase in pituitary stimulation.

Sermorelin Cost and Availability

Sermorelin's cost is often substantially less than HGH therapies. Many doctors are shifting their patients to Sermorelin to replace HGH injections due to its reduced cost and fewer side effects. Once the body generates adequate amounts of HGH, it triggers the release of insulin growth factor (IGF 1) in the liver, aiding in new cell growth and boosting metabolism.

Sermorelin Dosage and Benefits

Increased energy, improved sleep, and weight loss are notable benefits with a proper Sermorelin dosage. For some individuals, the combined use of testosterone and Sermorelin enhances the treatment's efficacy. The levels of IGF 1 in your system will determine the appropriate Sermorelin dosage.

Comparing GHRP 6 and Sermorelin

Though Growth Hormone Releasing Peptide or GHRP 6 acts similarly to Sermorelin, it binds to different receptors, increasing HGH secretion rates when combined. However, GHRP 6 is not FDA-approved and has been associated with excessive hunger and unnatural bone growth.

User Reviews of Sermorelin

As we age, our HGH levels significantly decline, leading to unpleasant side effects. By our 40s, our HGH levels have dropped by about 20 to 40% from their peak in our mid-20s. Many physicians today acknowledge the benefits of Sermorelin as a safe and effective way to stimulate increased HGH production instead of injecting HGH replacement therapy.

Starting Sermorelin and Testosterone Therapy

Prior to initiating a Sermorelin and testosterone protocol, blood panel tests are required for determining appropriate dosage, averting unnecessary side effects. Using blood panel data and medical history, one can devise a long-term plan to regain and stabilize healthy hormone levels. Sermorelin therapy focuses on naturally stimulating the pituitary gland to produce more HGH, presenting an alternative to HGH therapy, which relies on other bio-identical hormones to replenish levels.

Reference

"Sermorelin: A better approach to management of adult-onset growth hormone insufficiency?"

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