Reading Time: 2 minutesIntroduction Escitalopram, a widely prescribed selective serotonin reuptake inhibitor (SSRI), is commonly used to treat depression and anxiety disorders. For American males grappling with these conditions, understanding the safety profile of escitalopram, particularly in the context of liver diseases, is crucial. This article delves into the pharmacokinetics of escitalopram, its impact on liver function, and provides guidance on its use in patients with hepatic impairment. Pharmacokinetics of Escitalopram Escitalopram is metabolized primarily in the liver by the cytochrome P450 enzymes, specifically CYP3A4 and CYP2C19. The drug undergoes extensive first-pass metabolism, resulting in the formation of its primary metabolite, S-demethylcitalopram, which … Continue reading →